In pharmaceutical and biopharmaceutical production, the significance of high-purity solvents cannot be overstated. Solvents play a pivotal role in the optimisation of manufacturing processes for Active Pharmaceutical Ingredients (APIs). Solvents in fact account for 80-90% of the volume throughput of raw materials in a typical fine chemical process. As the pharmaceutical industry faces the ongoing challenges of quality control, regulatory compliance, and, more recently, supply chain constraints. Companies like NCC (The National Chemical Company) are at the forefront, providing indispensable solvents that ensure both quality continuity and a secure supply.
Solvents – the foundation of pharma production
At the heart of pharmaceutical synthesis, APIs are produced through chemical processes that demand precision and purity. High-purity pharmaceutical grade solvents, including but not limited to acetone, benzyl alcohol, ethanol, ethyl acetate, isopropyl alcohol (IPA), and propylene glycol (PG), form the essential building blocks. Our portfolio of REACH registered solvents includes: Acetonitrile, 1,3-Dimethyl-2-imidazolidinone, Anisole and Isopropyl Chloride. These solvents contribute not only to the efficacy of the final pharmaceutical products but also to the adherence to stringent quality standards required by regulatory bodies.
Slight impurities in a small sample might seem inconsequential but their impact becomes catastrophic when scaling up production. The presence of impurities has the potential to completely transform a formulation, resulting in an entirely different substance due to variations in chemical reactions. A notable example is the introduction of incorrect chemical components into a drug formulation, rendering the drug hazardous for human consumption.
When an active pharmaceutical ingredient carries impurities, it can lead to significant issues for a pharmaceutical manufacturer. Creating unexpected end results, this can result in huge costs, as well as wasted resources and time.
NCC’s commitment to excellence
NCC is an established and highly reliable sourcing and chemical distributor partner, addressing the industry’s core needs. Our commitment to excellence is reflected in the fact that we have longstanding working relationships with many major pharmaceutical manufacturers. NCC’s role extends beyond being a supplier; we serve as a strategic partner, providing accurate, on-time services, robust customer support, and unmatched supply chain expertise.
Ensuring supply chain security and continuity
Though it is commonplace for sourcing partners to have a fully integrated supply chain, there are significant differences when it comes to approaches and the actual management of the supply chain. It is not enough ensuring that the right product is delivered at the right time. It is important that a sourcing partner understands their customers goals and has the ability to deliver the right product at any time. This can only be achieved by analysing the vulnerabilities associated with specific supply chains and secondly working towards solutions that ensure a reduced impact to production when something unexpected goes wrong. Its moving from the risks of “just in time” to the comfort of “just in case”.
Can we assist?
Regardless if your organisation requires a solvent, intermediate or another type of raw material, we can assist. We have established relationships with trusted manufacturing partners as well as market expertise of the specific requirements of relevant manufacturing. Working closely with customers, we act as an extension of their team at every stage. With strong technical backgrounds and a deep understanding of the challenges that our customers have, solving their unique supply challenges is our primary goal. For further information call +353 1 613 1400 or fill out the form below and we’ll be in touch.
